Expression of CTB-50L17.10 in cancer - Summary

CANCER ATLAS

Gene description

Hepatoma-derived growth factor-related protein 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042559	HPA044208

GENE INFORMATION
Gene name	CTB-50L17.10
Synonyms
Description	Hepatoma-derived growth factor-related protein 2 (UniProtKB/Swiss-Prot)
Entrez gene summary	This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4472287 - 4502211
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167674 (version 83.38)
Entrez gene	84717
UniProt	Q7Z4V5 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4V5
Antibodypedia	CTB-50L17.10 antibodies

PROTEIN BROWSER

CTB-50L17.10-001	CTB-50L17.10-002	CTB-50L17.10-004	CTB-50L17.10-005	CTB-50L17.10-007	CTB-50L17.10-008	CTB-50L17.10-009	CTB-50L17.10-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTB-50L17.10-001 ENSP00000483345 ENST00000616600	Q7Z4V5 [Target identity:100%; Query identity:100%] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0030307 [positive regulation of cell growth] Show all	671 aa 74.3 kDa	No	0
CTB-50L17.10-002 ENSP00000483702 ENST00000621835		Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		670 aa 74.2 kDa	No	0
CTB-50L17.10-004 ENSP00000482480 ENST00000614903	A0A087WZ99 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.3 kDa	No	0
CTB-50L17.10-005 ENSP00000467513 ENST00000592417	K7EPS6 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] Show all	153 aa 16.8 kDa	No	0
CTB-50L17.10-007 ENSP00000468175 ENST00000587016	K7ERA4 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] Show all	175 aa 19.8 kDa	No	0
CTB-50L17.10-008 ENSP00000480754 ENST00000619255	A0A087WX58 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.3 kDa	No	0
CTB-50L17.10-009 ENSP00000467617 ENST00000592691	K7EQ06 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.4 kDa	No	0
CTB-50L17.10-010 ENSP00000465267 ENST00000589486	K7EJP7 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 12.7 kDa	No	0