Cell atlas - CTB-50L17.10 - The Human Protein Atlas

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CTB-50L17.10

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CTB-50L17.10
Gene description	Hepatoma-derived growth factor-related protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Nucleus in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA042559 , HPA044208
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA042559	A-431	Nucleoplasm
HPA042559	U-2 OS	Nucleus	Intensity
HPA042559	U-2 OS	Mitochondria	Intensity
HPA042559	U-251 MG	Nucleoplasm
HPA044208	A-431	Nucleoplasm
HPA044208	U-2 OS	Nucleoplasm
HPA044208	U-251 MG	Nucleoplasm

MOUSE CELLS

Main location

Nucleus

Mouse gene

ENSMUSG00000002833 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA044208	NIH 3T3	Nucleus

GENE INFORMATION
Gene name	CTB-50L17.10
Synonyms
Description	Hepatoma-derived growth factor-related protein 2 (UniProtKB/Swiss-Prot)
Entrez gene summary	This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4472287 - 4502211
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167674 (version 83.38)
Entrez gene	84717
UniProt	Q7Z4V5 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4V5
Antibodypedia	CTB-50L17.10 antibodies

PROTEIN BROWSER

CTB-50L17.10-001	CTB-50L17.10-002	CTB-50L17.10-004	CTB-50L17.10-005	CTB-50L17.10-007	CTB-50L17.10-008	CTB-50L17.10-009	CTB-50L17.10-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTB-50L17.10-001 ENSP00000483345 ENST00000616600	Q7Z4V5 [Target identity:100%; Query identity:100%] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0030307 [positive regulation of cell growth] Show all	671 aa 74.3 kDa	No	0
CTB-50L17.10-002 ENSP00000483702 ENST00000621835		Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		670 aa 74.2 kDa	No	0
CTB-50L17.10-004 ENSP00000482480 ENST00000614903	A0A087WZ99 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.3 kDa	No	0
CTB-50L17.10-005 ENSP00000467513 ENST00000592417	K7EPS6 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] Show all	153 aa 16.8 kDa	No	0
CTB-50L17.10-007 ENSP00000468175 ENST00000587016	K7ERA4 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] Show all	175 aa 19.8 kDa	No	0
CTB-50L17.10-008 ENSP00000480754 ENST00000619255	A0A087WX58 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.3 kDa	No	0
CTB-50L17.10-009 ENSP00000467617 ENST00000592691	K7EQ06 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		24 aa 2.4 kDa	No	0
CTB-50L17.10-010 ENSP00000465267 ENST00000589486	K7EJP7 [Direct mapping] Hepatoma-derived growth factor-related protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		121 aa 12.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.