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ZNF444

GENERAL INFORMATION

Gene name

 ZNF444

Gene description

 Zinc finger protein 444

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA056895
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZNF444 (HGNC Symbol)

Synonyms

 EZF2, FLJ11137, ZSCAN17

Description

 Zinc finger protein 444 (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 19

Cytoband

 q13.43

Chromosome location (bp)

 56132599 - 56160893

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167685 (version 83.38)

Entrez gene

 55311

UniProt

 Q8N0Y2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N0Y2

Antibodypedia

 ZNF444 antibodies

PROTEIN BROWSER
ZNF444-001
ZNF444-003
ZNF444-004
ZNF444-006
ZNF444-007
ZNF444-009
ZNF444-010
ZNF444-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF444-001
ENSP00000338860
ENST00000337080
Q8N0Y2 [Direct mapping]
Zinc finger protein 444
A0A024R4S5 [Target identity:100%; Query identity:100%]
Zinc finger protein 444, isoform CRA_b
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 327 aa
35.2 kDa 		No 0
ZNF444-003
ENSP00000466287
ENST00000588358
K7ELZ3 [Direct mapping]
Zinc finger protein 444
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 72 aa
8.3 kDa 		No 0
ZNF444-004
ENSP00000466666
ENST00000586123
K7EMV5 [Direct mapping]
Zinc finger protein 444
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 71 aa
8.2 kDa 		No 0
ZNF444-006
ENSP00000468762
ENST00000591564
K7ESL2 [Direct mapping]
Zinc finger protein 444
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 77 aa
8.8 kDa 		No 0
ZNF444-007
ENSP00000465466
ENST00000588203
K7EK55 [Direct mapping]
Zinc finger protein 444
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 44 aa
4.9 kDa 		No 0
ZNF444-009
ENSP00000465171
ENST00000587467
K7EJH4 [Direct mapping]
Zinc finger protein 444
Show all
Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 90 aa
10.3 kDa 		No 0
ZNF444-010
ENSP00000465070
ENST00000593100
K7EJ91 [Direct mapping]
Zinc finger protein 444
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 99 aa
11.3 kDa 		No 0
ZNF444-013
ENSP00000468069
ENST00000592949
Q8N0Y2 [Direct mapping]
Zinc finger protein 444
A0A024R4P4 [Target identity:100%; Query identity:100%]
Zinc finger protein 444, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 326 aa
35.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.