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Prostate cancers as well as cases of gliomas and thyroid cancers demonstrated moderate cytoplasmic positivity.
Remaining cancer tissues were generally negative.
Most cancer tissues displayed weak, often granular, cytoplasmic staining or were negative. Colorectal, ovarian, thyroid and testicular seminomas were moderately stained in a majority of cases.
GENE INFORMATION
Gene name
KLK5 (HGNC Symbol)
Synonyms
KLK-L2, SCTE
Description
Kallikrein-related peptidase 5 (HGNC Symbol)
Entrez gene summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
