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EVPL

GENERAL INFORMATION

Gene name

 EVPL

Gene description

 Envoplakin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (skin, esophagus)
GTEx:Tissue enhanced (esophagus, skin)
FANTOM5:Tissue enhanced (esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA053969 , CAB002220
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skin, esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, tonsil)

GENE INFORMATION

Gene name

 EVPL (HGNC Symbol)

Synonyms

 EVPK

Description

 Envoplakin (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 76004502 - 76027452

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167880 (version 83.38)

Entrez gene

 2125

UniProt

 Q92817 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92817

Antibodypedia

 EVPL antibodies

PROTEIN BROWSER
EVPL-001
EVPL-002
EVPL-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EVPL-001
ENSP00000301607
ENST00000301607
Q92817 [Direct mapping]
Envoplakin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0019215 [intermediate filament binding]
GO:0030057 [desmosome]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0031424 [keratinization]
GO:0070062 [extracellular exosome]
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 2033 aa
231.6 kDa 		No 0
EVPL-002
ENSP00000465630
ENST00000586740
K7EKI0 [Direct mapping]
Envoplakin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0008544 [epidermis development]
GO:0019215 [intermediate filament binding]
Show all
 2055 aa
233.8 kDa 		No 0
EVPL-005
ENSP00000467717
ENST00000589231
K7EQ87 [Direct mapping]
Envoplakin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0008544 [epidermis development]
GO:0019215 [intermediate filament binding]
Show all
 112 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.