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SOST

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GENERAL INFORMATION

Gene name

 SOST

Gene description

 Sclerostin

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SOST (HGNC Symbol)

Synonyms

 VBCH

Description

 Sclerostin (HGNC Symbol)

Entrez gene summary

 Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 43753731 - 43758788

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167941 (version 83.38)

Entrez gene

 50964

UniProt

 Q9BQB4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQB4

Antibodypedia

 SOST antibodies

PROTEIN BROWSER
SOST-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOST-001
ENSP00000301691
ENST00000301691
Q9BQB4 [Direct mapping]
Sclerostin
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005794 [Golgi apparatus]
GO:0008134 [transcription factor binding]
GO:0008201 [heparin binding]
GO:0009612 [response to mechanical stimulus]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030279 [negative regulation of ossification]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0031333 [negative regulation of protein complex assembly]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000054 [negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification]
Show all
 213 aa
24 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.