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SOST

GENERAL INFORMATION

Gene name

 SOST

Gene description

 Sclerostin

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (kidney)
GTEx:Tissue enriched (kidney)
FANTOM5:Tissue enhanced (retina, kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissue types.

DATA RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB025660
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina, kidney)

GENE INFORMATION

Gene name

 SOST (HGNC Symbol)

Synonyms

 VBCH

Description

 Sclerostin (HGNC Symbol)

Entrez gene summary

 Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 43753731 - 43758788

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167941 (version 83.38)

Entrez gene

 50964

UniProt

 Q9BQB4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQB4

Antibodypedia

 SOST antibodies

PROTEIN BROWSER
SOST-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOST-001
ENSP00000301691
ENST00000301691
Q9BQB4 [Direct mapping]
Sclerostin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005794 [Golgi apparatus]
GO:0008134 [transcription factor binding]
GO:0008201 [heparin binding]
GO:0009612 [response to mechanical stimulus]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030279 [negative regulation of ossification]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0031333 [negative regulation of protein complex assembly]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000054 [negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification]
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 213 aa
24 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.