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Cancer tissues displayed weak to moderate nuclear staining with additional cytoplasmic and/or membranous positivity in few cases. Rare case of urothelial cancer was strongly stained. Several cases of gliomas, lymphomas, renal and prostate cancers were negative.
GENE INFORMATION
Gene name
POLR2G (HGNC Symbol)
Synonyms
hRPB19, hsRPB7, RPB7
Description
Polymerase (RNA) II (DNA directed) polypeptide G (HGNC Symbol)
Entrez gene summary
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]