Fields »
ABOUT
HELP
BLOG
POLR2G

GENERAL INFORMATION

Gene name

 POLR2G

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide G

Protein class

 Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA053000
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 POLR2G (HGNC Symbol)

Synonyms

 hRPB19, hsRPB7, RPB7

Description

 Polymerase (RNA) II (DNA directed) polypeptide G (HGNC Symbol)

Entrez gene summary

 This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 62761544 - 62766710

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168002 (version 83.38)

Entrez gene

 5436

UniProt

 P62487 (UniProt - Evidence at protein level)

neXtProt

 NX_P62487

Antibodypedia

 POLR2G antibodies

PROTEIN BROWSER
POLR2G-001
POLR2G-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2G-001
ENSP00000301788
ENST00000301788
P62487 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB7
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000291 [nuclear-transcribed mRNA catabolic process, exonucleolytic]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006915 [apoptotic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0031369 [translation initiation factor binding]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0045948 [positive regulation of translational initiation]
GO:0050434 [positive regulation of viral transcription]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
Show all
 172 aa
19.3 kDa 		No 0
POLR2G-005
ENSP00000432198
ENST00000533442
E9PS03 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB7
Show all
Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000291 [nuclear-transcribed mRNA catabolic process, exonucleolytic]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003697 [single-stranded DNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0031369 [translation initiation factor binding]
GO:0045948 [positive regulation of translational initiation]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
Show all
 13 aa
1.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.