Tissue expression of SLC3A2 - Summary - The Human Protein Atlas

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SLC3A2

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC3A2
Gene description	Solute carrier family 3 (amino acid transporter heavy chain), member 2
Protein class	Cancer-related genes CD markers Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in several cell types, mainly in seminiferous ducts, islets of Langerhans, squamous epithelial cells and renal proximal tubules.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA017980 , CAB010455
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SLC3A2 (HGNC Symbol)
Synonyms	4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Description	Solute carrier family 3 (amino acid transporter heavy chain), member 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62856102 - 62888875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168003 (version 83.38)
Entrez gene	6520
UniProt	P08195 (UniProt - Evidence at protein level)
neXtProt	NX_P08195
Antibodypedia	SLC3A2 antibodies

PROTEIN BROWSER

SLC3A2-001	SLC3A2-002	SLC3A2-003	SLC3A2-004	SLC3A2-005	SLC3A2-006	SLC3A2-007	SLC3A2-012	SLC3A2-019	SLC3A2-021	SLC3A2-022	SLC3A2-026

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC3A2-001 ENSP00000367122 ENST00000377890	P08195 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003725 [double-stranded RNA binding] GO:0003824 [catalytic activity] GO:0005432 [calcium:sodium antiporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015827 [tryptophan transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0016324 [apical plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0042470 [melanosome] GO:0043169 [cation binding] GO:0043330 [response to exogenous dsRNA] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:0060356 [leucine import] GO:0070062 [extracellular exosome] Show all	630 aa 68 kDa	No	2
SLC3A2-002 ENSP00000367121 ENST00000377889	P08195 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003725 [double-stranded RNA binding] GO:0003824 [catalytic activity] GO:0005432 [calcium:sodium antiporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015827 [tryptophan transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0016324 [apical plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0042470 [melanosome] GO:0043169 [cation binding] GO:0043330 [response to exogenous dsRNA] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:0060356 [leucine import] GO:0070062 [extracellular exosome] Show all	568 aa 61.8 kDa	No	2
SLC3A2-003 ENSP00000367123 ENST00000377891	J3KPF3 [Direct mapping] 4F2 cell-surface antigen heavy chain; Solute carrier family 3 (Activators of dibasic and neutral amino acid transport), member 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0016021 [integral component of membrane] GO:0043169 [cation binding] Show all	631 aa 68.1 kDa	No	2
SLC3A2-004 ENSP00000340815 ENST00000338663	P08195 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003725 [double-stranded RNA binding] GO:0003824 [catalytic activity] GO:0005432 [calcium:sodium antiporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006865 [amino acid transport] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0015175 [neutral amino acid transmembrane transporter activity] GO:0015827 [tryptophan transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0016324 [apical plasma membrane] GO:0035725 [sodium ion transmembrane transport] GO:0042470 [melanosome] GO:0043169 [cation binding] GO:0043330 [response to exogenous dsRNA] GO:0044822 [poly(A) RNA binding] GO:0050900 [leukocyte migration] GO:0055085 [transmembrane transport] GO:0060356 [leucine import] GO:0070062 [extracellular exosome] Show all	529 aa 57.9 kDa	No	2
SLC3A2-005 ENSP00000440001 ENST00000538084	H0YFS2 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	247 aa 26 kDa	No	1
SLC3A2-006 ENSP00000442135 ENST00000544377	F5H867 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	135 aa 14.8 kDa	No	1
SLC3A2-007 ENSP00000438032 ENST00000539458	F5H0E2 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0016021 [integral component of membrane] GO:0043169 [cation binding] Show all	145 aa 15.8 kDa	No	1
SLC3A2-012 ENSP00000438353 ENST00000539891	F5H056 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	67 aa 7 kDa	No	0
SLC3A2-019 ENSP00000440819 ENST00000539507	H0YFX4 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	122 aa 13.2 kDa	No	0
SLC3A2-021 ENSP00000444250 ENST00000541372	F5GZR9 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	47 aa 5.3 kDa	No	0
SLC3A2-022 ENSP00000444439 ENST00000536981	F5GZI0 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] Show all	175 aa 19 kDa	No	0
SLC3A2-026 ENSP00000444236 ENST00000535296	F5GZS6 [Direct mapping] 4F2 cell-surface antigen heavy chain Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0016021 [integral component of membrane] GO:0043169 [cation binding] Show all	599 aa 64.9 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.