Cell atlas - PBK - The Human Protein Atlas

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PBK

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PBK
Gene description	PDZ binding kinase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA005753
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005753	A-431	Cytosol
	HPA005753	U-2 OS	Cytosol

GENE INFORMATION
Gene name	PBK (HGNC Symbol)
Synonyms	CT84, FLJ14385, Nori-3, SPK, TOPK
Description	PDZ binding kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	8
Cytoband	p21.1
Chromosome location (bp)	27809620 - 27838095
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168078 (version 83.38)
Entrez gene	55872
UniProt	Q96KB5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KB5
Antibodypedia	PBK antibodies

PROTEIN BROWSER

PBK-001	PBK-002	PBK-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PBK-001 ENSP00000301905 ENST00000301905	Q96KB5 [Direct mapping] Lymphokine-activated killer T-cell-originated protein kinase V9HWH0 [Target identity:100%; Query identity:100%] Epididymis luminal protein 164 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] Show all	322 aa 36.1 kDa	No	0
PBK-002 ENSP00000428489 ENST00000522944	Q96KB5 [Direct mapping] Lymphokine-activated killer T-cell-originated protein kinase Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0034644 [cellular response to UV] GO:0050728 [negative regulation of inflammatory response] Show all	333 aa 37.2 kDa	No	0
PBK-005 ENSP00000427892 ENST00000521226	E5RFX4 [Direct mapping] Lymphokine-activated killer T-cell-originated protein kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	151 aa 17.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.