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This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Q96KB5 [Direct mapping] Lymphokine-activated killer T-cell-originated protein kinase V9HWH0 [Target identity:100%; Query identity:100%] Epididymis luminal protein 164
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q96KB5 [Direct mapping] Lymphokine-activated killer T-cell-originated protein kinase
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014)
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GO:0001933 [negative regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007067 [mitotic nuclear division] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0034644 [cellular response to UV] GO:0050728 [negative regulation of inflammatory response]
