Cell atlas - PNOC - The Human Protein Atlas

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PNOC

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PNOC
Gene description	Prepronociceptin
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (Daudi, Karpas-707, U-698, RPMI-8226)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (Daudi, Karpas-707, U-698, RPMI-8226) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PNOC (HGNC Symbol)
Synonyms	N/OFQ, NOP, PPNOC
Description	Prepronociceptin (HGNC Symbol)
Entrez gene summary	This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
Chromosome	8
Cytoband	p21.1
Chromosome location (bp)	28316986 - 28343355
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168081 (version 83.38)
Entrez gene	5368
UniProt	Q13519 (UniProt - Evidence at protein level)
neXtProt	NX_Q13519
Antibodypedia	PNOC antibodies

PROTEIN BROWSER

PNOC-001	PNOC-002	PNOC-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNOC-001 ENSP00000301908 ENST00000301908	Q13519 [Direct mapping] Prepronociceptin Nocistatin Nociceptin Orphanin FQ2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001515 [opioid peptide activity] GO:0005184 [neuropeptide hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0007565 [female pregnancy] GO:0007600 [sensory perception] Show all	176 aa 20.3 kDa	Yes	0
PNOC-002 ENSP00000430145 ENST00000522209	Q13519 [Direct mapping] Prepronociceptin Nocistatin Nociceptin Orphanin FQ2 Show all	Predicted intracellular proteins Show all	GO:0001515 [opioid peptide activity] GO:0005184 [neuropeptide hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007600 [sensory perception] Show all	112 aa 13 kDa	No	0
PNOC-004 ENSP00000428059 ENST00000518479	E7EVP0 [Direct mapping] Prepronociceptin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001515 [opioid peptide activity] GO:0005576 [extracellular region] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] Show all	154 aa 17.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.