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PNOC

GENERAL INFORMATION

Gene name

 PNOC

Gene description

 Prepronociceptin

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, lymph node, fallopian tube)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (tonsil, appendix)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in a subset of neurons in cerebral cortex.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA044507 , HPA056724
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, lymph node, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (tonsil, appendix)

GENE INFORMATION

Gene name

 PNOC (HGNC Symbol)

Synonyms

 N/OFQ, NOP, PPNOC

Description

 Prepronociceptin (HGNC Symbol)

Entrez gene summary

 This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]

Chromosome

 8

Cytoband

 p21.1

Chromosome location (bp)

 28316986 - 28343355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168081 (version 83.38)

Entrez gene

 5368

UniProt

 Q13519 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13519

Antibodypedia

 PNOC antibodies

PROTEIN BROWSER
PNOC-001
PNOC-002
PNOC-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PNOC-001
ENSP00000301908
ENST00000301908
Q13519 [Direct mapping]
Prepronociceptin Nocistatin Nociceptin Orphanin FQ2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001515 [opioid peptide activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007565 [female pregnancy]
GO:0007600 [sensory perception]
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 176 aa
20.3 kDa 		Yes 0
PNOC-002
ENSP00000430145
ENST00000522209
Q13519 [Direct mapping]
Prepronociceptin Nocistatin Nociceptin Orphanin FQ2
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Predicted intracellular proteins
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GO:0001515 [opioid peptide activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007600 [sensory perception]
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 112 aa
13 kDa 		No 0
PNOC-004
ENSP00000428059
ENST00000518479
E7EVP0 [Direct mapping]
Prepronociceptin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001515 [opioid peptide activity]
GO:0005576 [extracellular region]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
Show all
 154 aa
17.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.