Expression of HOOK3 in cancer - Summary

CANCER ATLAS

Gene description

Hook microtubule-tethering protein 3

Protein class

Cancer-related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024756

GENE INFORMATION
Gene name	HOOK3 (HGNC Symbol)
Synonyms	HK3
Description	Hook microtubule-tethering protein 3 (HGNC Symbol)
Entrez gene summary	Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42896932 - 43030539
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168172 (version 83.38)
Entrez gene	84376
UniProt	Q86VS8 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VS8
Antibodypedia	HOOK3 antibodies

PROTEIN BROWSER

HOOK3-001	HOOK3-005	HOOK3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOOK3-001 ENSP00000305699 ENST00000307602	Q86VS8 [Direct mapping] Protein Hook homolog 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000242 [pericentriolar material] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0007032 [endosome organization] GO:0007040 [lysosome organization] GO:0008017 [microtubule binding] GO:0008333 [endosome to lysosome transport] GO:0015031 [protein transport] GO:0022027 [interkinetic nuclear migration] GO:0030897 [HOPS complex] GO:0031122 [cytoplasmic microtubule organization] GO:0034451 [centriolar satellite] GO:0034454 [microtubule anchoring at centrosome] GO:0042802 [identical protein binding] GO:0045022 [early endosome to late endosome transport] GO:0050768 [negative regulation of neurogenesis] GO:0051645 [Golgi localization] GO:0070695 [FHF complex] GO:0071539 [protein localization to centrosome] GO:0097150 [neuronal stem cell population maintenance] Show all	718 aa 83.1 kDa	No	0
HOOK3-005 ENSP00000433953 ENST00000533539	H0YDM4 [Direct mapping] Protein Hook homolog 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		161 aa 19.1 kDa	No	0
HOOK3-006 ENSP00000433813 ENST00000533338	H0YDK4 [Direct mapping] Protein Hook homolog 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.3 kDa	No	0