Cell atlas - HOOK3 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HOOK3
Gene description	Hook microtubule-tethering protein 3
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubule organizing center. In addition localized to the cytosol & the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (supported)
Additional location	In addition localized to the Golgi apparatus (supported), Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA024756
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubule organizing center. In addition localized to the cytosol & the Golgi apparatus.

Main location

Microtubule organizing center (supported)

Additional location

Golgi apparatus (supported), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA024756	A-431	Microtubule organizing center
HPA024756	A-431	Cytosol
HPA024756	U-2 OS	Golgi apparatus
		Microtubule organizing center
		Cytosol
HPA024756	U-251 MG	Microtubule organizing center
HPA024756	U-251 MG	Cytosol

GENE INFORMATION
Gene name	HOOK3 (HGNC Symbol)
Synonyms	HK3
Description	Hook microtubule-tethering protein 3 (HGNC Symbol)
Entrez gene summary	Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42896932 - 43030539
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168172 (version 83.38)
Entrez gene	84376
UniProt	Q86VS8 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VS8
Antibodypedia	HOOK3 antibodies

PROTEIN BROWSER

HOOK3-001	HOOK3-005	HOOK3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOOK3-001 ENSP00000305699 ENST00000307602	Q86VS8 [Direct mapping] Protein Hook homolog 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000242 [pericentriolar material] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005874 [microtubule] GO:0007032 [endosome organization] GO:0007040 [lysosome organization] GO:0008017 [microtubule binding] GO:0008333 [endosome to lysosome transport] GO:0015031 [protein transport] GO:0022027 [interkinetic nuclear migration] GO:0030897 [HOPS complex] GO:0031122 [cytoplasmic microtubule organization] GO:0034451 [centriolar satellite] GO:0034454 [microtubule anchoring at centrosome] GO:0042802 [identical protein binding] GO:0045022 [early endosome to late endosome transport] GO:0050768 [negative regulation of neurogenesis] GO:0051645 [Golgi localization] GO:0070695 [FHF complex] GO:0071539 [protein localization to centrosome] GO:0097150 [neuronal stem cell population maintenance] Show all	718 aa 83.1 kDa	No	0
HOOK3-005 ENSP00000433953 ENST00000533539	H0YDM4 [Direct mapping] Protein Hook homolog 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		161 aa 19.1 kDa	No	0
HOOK3-006 ENSP00000433813 ENST00000533338	H0YDK4 [Direct mapping] Protein Hook homolog 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.3 kDa	No	0