Cell atlas - COA6 - The Human Protein Atlas

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COA6

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	COA6
Gene description	Cytochrome c oxidase assembly factor 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA028588
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028588	A-431	Mitochondria
	HPA028588	U-2 OS	Nucleoplasm
	HPA028588	U-2 OS	Mitochondria
	HPA028588	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	COA6 (HGNC Symbol)
Synonyms	C1orf31
Description	Cytochrome c oxidase assembly factor 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Chromosome	1
Cytoband	q42.2
Chromosome location (bp)	234373456 - 234384049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168275 (version 83.38)
Entrez gene	388753
UniProt	Q5JTJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5JTJ3
Antibodypedia	COA6 antibodies

PROTEIN BROWSER

COA6-001	COA6-002	COA6-003	COA6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COA6-001 ENSP00000355574 ENST00000366615	X6R5Z6 [Direct mapping] Cytochrome c oxidase assembly factor 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:1902600 [hydrogen ion transmembrane transport] Show all	155 aa 18 kDa	No	0
COA6-002 ENSP00000355572 ENST00000366613	Q5JTJ3 [Direct mapping] Cytochrome c oxidase assembly factor 6 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0008150 [biological_process] GO:0044822 [poly(A) RNA binding] GO:1902600 [hydrogen ion transmembrane transport] Show all	125 aa 14.1 kDa	No	0
COA6-003 ENSP00000355571 ENST00000366612	Q5JTJ3 [Direct mapping] Cytochrome c oxidase assembly factor 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0008150 [biological_process] GO:0044822 [poly(A) RNA binding] GO:1902600 [hydrogen ion transmembrane transport] Show all	79 aa 9.4 kDa	No	0
COA6-201 ENSP00000479686 ENST00000619305	Q5JTJ3 [Direct mapping] Cytochrome c oxidase assembly factor 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0008150 [biological_process] GO:0044822 [poly(A) RNA binding] GO:1902600 [hydrogen ion transmembrane transport] Show all	79 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.