Expression of MGAT2 in cancer - Summary

CANCER ATLAS

Gene description

Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043721

GENE INFORMATION
Gene name	MGAT2 (HGNC Symbol)
Synonyms	GNT-II
Description	Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (HGNC Symbol)
Entrez gene summary	The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q21.3
Chromosome location (bp)	49620795 - 49623481
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168282 (version 83.38)
Entrez gene	4247
UniProt	Q10469 (UniProt - Evidence at protein level)
neXtProt	NX_Q10469
Antibodypedia	MGAT2 antibodies

PROTEIN BROWSER

MGAT2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGAT2-001 ENSP00000307423 ENST00000305386	Q10469 [Direct mapping] Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005794 [Golgi apparatus] GO:0005795 [Golgi stack] GO:0006487 [protein N-linked glycosylation] GO:0008455 [alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity] GO:0009311 [oligosaccharide metabolic process] GO:0009312 [oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	447 aa 51.5 kDa	Yes	0