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MGAT2

GENERAL INFORMATION

Gene name

 MGAT2

Gene description

 Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA043721
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MGAT2 (HGNC Symbol)

Synonyms

 GNT-II

Description

 Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (HGNC Symbol)

Entrez gene summary

 The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q21.3

Chromosome location (bp)

 49620795 - 49623481

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168282 (version 83.38)

Entrez gene

 4247

UniProt

 Q10469 (UniProt - Evidence at protein level)

neXtProt

 NX_Q10469

Antibodypedia

 MGAT2 antibodies

PROTEIN BROWSER
MGAT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MGAT2-001
ENSP00000307423
ENST00000305386
Q10469 [Direct mapping]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006487 [protein N-linked glycosylation]
GO:0008455 [alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity]
GO:0009311 [oligosaccharide metabolic process]
GO:0009312 [oligosaccharide biosynthetic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030246 [carbohydrate binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
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 447 aa
51.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.