Cell atlas - THAP11 - The Human Protein Atlas

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THAP11

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytokinetic bridge
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	THAP11
Gene description	THAP domain containing 11
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytokinetic bridge (validated)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA041434 , HPA042189
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge.

Main location

Nucleoplasm (validated)

Additional location

Cytokinetic bridge (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA041434	A-431	Cytosol	Intensity
HPA041434	U-2 OS	Nucleoplasm
HPA041434	U-2 OS	Cytosol
HPA042189	A-431	Nucleoplasm
HPA042189	U-2 OS	Nucleoplasm
HPA042189	U-2 OS	Cytokinetic bridge	Intensity	Intensity
HPA042189	U-251 MG	Nucleoplasm
HPA042189	U-251 MG	Cytokinetic bridge	Intensity	Intensity

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

GENE INFORMATION
Gene name	THAP11 (HGNC Symbol)
Synonyms	CTG-B43a, CTG-B45d, HRIHFB2206
Description	THAP domain containing 11 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q22.1
Chromosome location (bp)	67842082 - 67844195
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168286 (version 83.38)
Entrez gene	57215
UniProt	Q96EK4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96EK4
Antibodypedia	THAP11 antibodies

PROTEIN BROWSER

THAP11-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THAP11-001 ENSP00000304689 ENST00000303596	Q96EK4 [Direct mapping] THAP domain-containing protein 11 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0045171 [intercellular bridge] Show all	314 aa 34.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.