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BMP1

GENERAL INFORMATION

Gene name

 BMP1

Gene description

 Bone morphogenetic protein 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Expressed in all
FANTOM5:Group enriched (placenta, lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA014572
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, lung)

GENE INFORMATION

Gene name

 BMP1 (HGNC Symbol)

Synonyms

 PCOLC

Description

 Bone morphogenetic protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22164736 - 22212326

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168487 (version 83.38)

Entrez gene

 649

UniProt

 P13497 (UniProt - Evidence at protein level)

neXtProt

 NX_P13497

Antibodypedia

 BMP1 antibodies

PROTEIN BROWSER
BMP1-001
BMP1-010
BMP1-201
BMP1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMP1-001
ENSP00000305714
ENST00000306385
P13497 [Direct mapping]
Bone morphogenetic protein 1
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001503 [ossification]
GO:0004222 [metalloendopeptidase activity]
GO:0005125 [cytokine activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005794 [Golgi apparatus]
GO:0006508 [proteolysis]
GO:0007275 [multicellular organismal development]
GO:0008083 [growth factor activity]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0031988 [membrane-bounded vesicle]
GO:0042157 [lipoprotein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0061036 [positive regulation of cartilage development]
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 986 aa
111.2 kDa 		Yes 0
BMP1-010
ENSP00000306121
ENST00000306349
P13497 [Direct mapping]
Bone morphogenetic protein 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001503 [ossification]
GO:0004222 [metalloendopeptidase activity]
GO:0005125 [cytokine activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005794 [Golgi apparatus]
GO:0006508 [proteolysis]
GO:0007275 [multicellular organismal development]
GO:0008083 [growth factor activity]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
GO:0042157 [lipoprotein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0061036 [positive regulation of cartilage development]
Show all
 730 aa
82.9 kDa 		Yes 0
BMP1-201
ENSP00000346941
ENST00000354870
Q3MIM8 [Direct mapping]
Metalloendopeptidase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
Show all
 302 aa
33.4 kDa 		Yes 0
BMP1-202
ENSP00000380915
ENST00000397814
B7ZKR5 [Direct mapping]
BMP1 protein; Bone morphogenetic protein 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
Show all
 189 aa
21 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.