Cell atlas - SDPR - The Human Protein Atlas

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SDPR

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SDPR
Gene description	Serum deprivation response
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol.
RNA cell category	Group enriched (LHCN-M2, HUVEC TERT2, TIME, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA039325 , HPA062122
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (LHCN-M2, HUVEC TERT2, TIME, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol.

Main location

Plasma membrane (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA039325	Hep G2	Plasma membrane
HPA039325	Hep G2	Cytosol	Intensity
HPA039325	RH-30	Plasma membrane
HPA039325	RH-30	Cytosol
HPA039325	U-2 OS	Plasma membrane
HPA062122	Hep G2	Plasma membrane
HPA062122	Hep G2	Cytosol
HPA062122	RH-30	Plasma membrane
HPA062122	U-2 OS	Nucleoplasm
		Plasma membrane
		Actin filaments

GENE INFORMATION
Gene name	SDPR (HGNC Symbol)
Synonyms	cavin-2, CAVIN2, PS-p68, SDR
Description	Serum deprivation response (HGNC Symbol)
Entrez gene summary	This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Chromosome	2
Cytoband	q32.3
Chromosome location (bp)	191834302 - 191847255
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168497 (version 83.38)
Entrez gene	8436
UniProt	O95810 (UniProt - Evidence at protein level)
neXtProt	NX_O95810
Antibodypedia	SDPR antibodies

PROTEIN BROWSER

SDPR-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDPR-001 ENSP00000305675 ENST00000304141	O95810 [Direct mapping] Serum deprivation-response protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005901 [caveola] GO:0045121 [membrane raft] Show all	425 aa 47.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.