Cell atlas - ZBTB49 - The Human Protein Atlas

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ZBTB49

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubules
	Nucleoplasm

Human cell
	Cytosol
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZBTB49
Gene description	Zinc finger and BTB domain containing 49
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & microtubules.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Microtubules (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA024450
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & microtubules.

Main location

Nucleoplasm (approved)

Additional location

Microtubules (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024450	A-431	Nucleoplasm
	HPA024450	A-431	Cytosol
	HPA024450	U-2 OS	No staining
	HPA024450	U-251 MG	Nucleoplasm
			Microtubules
			Cytosol

GENE INFORMATION
Gene name	ZBTB49 (HGNC Symbol)
Synonyms	FLJ38559, ZNF509
Description	Zinc finger and BTB domain containing 49 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	4290251 - 4321786
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168826 (version 83.38)
Entrez gene	166793
UniProt	Q6ZSB9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZSB9
Antibodypedia	ZBTB49 antibodies

PROTEIN BROWSER

ZBTB49-001	ZBTB49-004	ZBTB49-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZBTB49-001 ENSP00000338807 ENST00000337872	Q6ZSB9 [Direct mapping] Zinc finger and BTB domain-containing protein 49 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001223 [transcription coactivator binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007050 [cell cycle arrest] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	765 aa 85.1 kDa	No	0
ZBTB49-004 ENSP00000425747 ENST00000502918	D6RJ00 [Direct mapping] Zinc finger and BTB domain-containing protein 49 Show all	Predicted intracellular proteins Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	146 aa 16.2 kDa	No	0
ZBTB49-005 ENSP00000421654 ENST00000504302	H0Y8P2 [Direct mapping] Zinc finger and BTB domain-containing protein 49 Show all	Predicted intracellular proteins Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	174 aa 19.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.