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ZBTB49

GENERAL INFORMATION

Gene name

 ZBTB49

Gene description

 Zinc finger and BTB domain containing 49

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Membranous positivity in gastrointestinal tract and kidney was viewed as off target and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA024450
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZBTB49 (HGNC Symbol)

Synonyms

 FLJ38559, ZNF509

Description

 Zinc finger and BTB domain containing 49 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 4290251 - 4321786

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168826 (version 83.38)

Entrez gene

 166793

UniProt

 Q6ZSB9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZSB9

Antibodypedia

 ZBTB49 antibodies

PROTEIN BROWSER
ZBTB49-001
ZBTB49-004
ZBTB49-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZBTB49-001
ENSP00000338807
ENST00000337872
Q6ZSB9 [Direct mapping]
Zinc finger and BTB domain-containing protein 49
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001223 [transcription coactivator binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
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 765 aa
85.1 kDa 		No 0
ZBTB49-004
ENSP00000425747
ENST00000502918
D6RJ00 [Direct mapping]
Zinc finger and BTB domain-containing protein 49
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Predicted intracellular proteins
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
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 146 aa
16.2 kDa 		No 0
ZBTB49-005
ENSP00000421654
ENST00000504302
H0Y8P2 [Direct mapping]
Zinc finger and BTB domain-containing protein 49
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Predicted intracellular proteins
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 174 aa
19.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.