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TNIP2

GENERAL INFORMATION

Gene name

 TNIP2

Gene description

 TNFAIP3 interacting protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and nuclear expression

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA049886 , HPA063197 , CAB020818
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TNIP2 (HGNC Symbol)

Synonyms

 ABIN-2, FLIP1, KLIP, MGC4289

Description

 TNFAIP3 interacting protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 2741648 - 2756376

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168884 (version 83.38)

Entrez gene

 79155

UniProt

 Q8NFZ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFZ5

Antibodypedia

 TNIP2 antibodies

PROTEIN BROWSER
TNIP2-001
TNIP2-002
TNIP2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNIP2-001
ENSP00000321203
ENST00000315423
Q8NFZ5 [Direct mapping]
TNFAIP3-interacting protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0019901 [protein kinase binding]
GO:0023035 [CD40 signaling pathway]
GO:0031593 [polyubiquitin binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043032 [positive regulation of macrophage activation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050821 [protein stabilization]
GO:0050871 [positive regulation of B cell activation]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 429 aa
48.7 kDa 		No 0
TNIP2-002
ENSP00000427613
ENST00000510267
Q8NFZ5 [Direct mapping]
TNFAIP3-interacting protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0019901 [protein kinase binding]
GO:0023035 [CD40 signaling pathway]
GO:0031593 [polyubiquitin binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043032 [positive regulation of macrophage activation]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050821 [protein stabilization]
GO:0050871 [positive regulation of B cell activation]
GO:0051403 [stress-activated MAPK cascade]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 322 aa
36.7 kDa 		No 0
TNIP2-003
ENSP00000426314
ENST00000503235
D6RGJ2 [Direct mapping]
TNFAIP3-interacting protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 346 aa
38.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.