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VAMP5

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GENERAL INFORMATION

Gene name

 VAMP5

Gene description

 Vesicle-associated membrane protein 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.

RNA cell category

 Cell line enhanced (LHCN-M2, HUVEC TERT2, TIME)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA035082
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (LHCN-M2, HUVEC TERT2, TIME)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the plasma membrane.

Main location

 Nucleoplasm (approved)

Additional location

 Plasma membrane (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035082 BJ Nucleoplasm
Plasma membrane

GENE INFORMATION

Gene name

 VAMP5

Synonyms

Description

 Vesicle-associated membrane protein 5 (HGNC Symbol)

Entrez gene summary

 Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 85584408 - 85593412

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168899 (version 83.38)

Entrez gene

 10791

UniProt

 O95183 (UniProt - Evidence at protein level)

neXtProt

 NX_O95183

Antibodypedia

 VAMP5 antibodies

PROTEIN BROWSER
VAMP5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VAMP5-001
ENSP00000305647
ENST00000306384
O95183 [Direct mapping]
Vesicle-associated membrane protein 5
Q6FG93 [Target identity:100%; Query identity:100%]
HCG34604, isoform CRA_c; Putative uncharacterized protein VAMP5; VAMP5 protein; cDNA FLJ76424, highly similar to Homo sapiens HSPC191 mRNA
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006887 [exocytosis]
GO:0006906 [vesicle fusion]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0008021 [synaptic vesicle]
GO:0009986 [cell surface]
GO:0014704 [intercalated disc]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030154 [cell differentiation]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031201 [SNARE complex]
GO:0031301 [integral component of organelle membrane]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 116 aa
12.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.