Expression of CEP120 in cancer - Summary

CANCER ATLAS

Gene description

Centrosomal protein 120kDa

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Endometrial cancer

STAINING SUMMARY

HPA028823	HPA051556

GENE INFORMATION
Gene name	CEP120 (HGNC Symbol)
Synonyms	CCDC100, FLJ36090
Description	Centrosomal protein 120kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	5
Cytoband	q23.2
Chromosome location (bp)	123344885 - 123423592
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168944 (version 83.38)
Entrez gene	153241
UniProt	Q8N960 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N960
Antibodypedia	CEP120 antibodies

PROTEIN BROWSER

CEP120-001	CEP120-002	CEP120-005	CEP120-009	CEP120-201	CEP120-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP120-001 ENSP00000303058 ENST00000306467	Q8N960 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0021987 [cerebral cortex development] GO:0022008 [neurogenesis] GO:0022027 [interkinetic nuclear migration] GO:0030953 [astral microtubule organization] GO:0032880 [regulation of protein localization] GO:0032886 [regulation of microtubule-based process] Show all	986 aa 112.6 kDa	No	0
CEP120-002 ENSP00000421620 ENST00000508442	D6REX9 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	844 aa 95.9 kDa	No	0
CEP120-005 ENSP00000428303 ENST00000515110	E5RJ50 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.8 kDa	No	0
CEP120-009 ENSP00000422382 ENST00000510582	F8VRV0 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	165 aa 18.6 kDa	No	0
CEP120-201 ENSP00000307419 ENST00000306481	Q8N960 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	960 aa 109.6 kDa	No	0
CEP120-202 ENSP00000327504 ENST00000328236	Q8N960 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	986 aa 112.6 kDa	No	0