Cell atlas - CEP120 - The Human Protein Atlas

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CEP120

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubules

Human cell
	Cytosol
	Microtubules

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GENERAL INFORMATION
Gene name	CEP120
Gene description	Centrosomal protein 120kDa
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028823
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the cytosol.

Main location

Microtubules (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028823	A-431	Microtubules
	HPA028823	A-431	Cytosol
	HPA028823	U-2 OS	Microtubules
	HPA028823	U-251 MG	Microtubules
	HPA028823	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CEP120 (HGNC Symbol)
Synonyms	CCDC100, FLJ36090
Description	Centrosomal protein 120kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	5
Cytoband	q23.2
Chromosome location (bp)	123344885 - 123423592
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168944 (version 83.38)
Entrez gene	153241
UniProt	Q8N960 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N960
Antibodypedia	CEP120 antibodies

PROTEIN BROWSER

CEP120-001	CEP120-002	CEP120-005	CEP120-009	CEP120-201	CEP120-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP120-001 ENSP00000303058 ENST00000306467	Q8N960 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0008022 [protein C-terminus binding] GO:0008283 [cell proliferation] GO:0021987 [cerebral cortex development] GO:0022008 [neurogenesis] GO:0022027 [interkinetic nuclear migration] GO:0030953 [astral microtubule organization] GO:0032880 [regulation of protein localization] GO:0032886 [regulation of microtubule-based process] Show all	986 aa 112.6 kDa	No	0
CEP120-002 ENSP00000421620 ENST00000508442	D6REX9 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	844 aa 95.9 kDa	No	0
CEP120-005 ENSP00000428303 ENST00000515110	E5RJ50 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.8 kDa	No	0
CEP120-009 ENSP00000422382 ENST00000510582	F8VRV0 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	165 aa 18.6 kDa	No	0
CEP120-201 ENSP00000307419 ENST00000306481	Q8N960 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	960 aa 109.6 kDa	No	0
CEP120-202 ENSP00000327504 ENST00000328236	Q8N960 [Direct mapping] Centrosomal protein of 120 kDa Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	986 aa 112.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.