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Most malignant gliomas and several cases of prostate and urothelial cancers showed moderate cytoplasmic positivity. Other malignancies were in general weakly stained or negative.
GENE INFORMATION
Gene name
IRS1 (HGNC Symbol)
Synonyms
HIRS-1
Description
Insulin receptor substrate 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]