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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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IRS1
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

IRS1

Gene description

Insulin receptor substrate 1

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and/or nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
CAB005261
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

IRS1 (HGNC Symbol)

Synonyms

HIRS-1

Description

Insulin receptor substrate 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

Chromosome

2

Cytoband

q36.3

Chromosome location (bp)

226731317 - 226799759

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169047 (version 83.38)

Entrez gene

3667

UniProt

P35568 (UniProt - Evidence at protein level)

neXtProt

NX_P35568

Antibodypedia

IRS1 antibodies

PROTEIN BROWSER

IRS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IRS1-001
ENSP00000304895
ENST00000305123
P35568 [Direct mapping]
Insulin receptor substrate 1
A0A024R499 [Target identity:100%; Query identity:100%]
Insulin receptor substrate 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0004871 [signal transducer activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005080 [protein kinase C binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005899 [insulin receptor complex]
GO:0005901 [caveola]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010468 [regulation of gene expression]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016042 [lipid catabolic process]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0030879 [mammary gland development]
GO:0032000 [positive regulation of fatty acid beta-oxidation]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0034504 [protein localization to nucleus]
GO:0036064 [ciliary basal body]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042169 [SH2 domain binding]
GO:0042593 [glucose homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043434 [response to peptide hormone]
GO:0043491 [protein kinase B signaling]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046676 [negative regulation of insulin secretion]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Show all
1242 aa
131.6 kDa
No 0

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