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AR

CANCER ATLAS

Gene description

 Androgen receptor

Protein class

 Cancer-related genes, Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB000001
CAB065764

GENE INFORMATION

Gene name

 AR (HGNC Symbol)

Synonyms

 AIS, DHTR, HUMARA, NR3C4, SBMA, SMAX1

Description

 Androgen receptor (HGNC Symbol)

Entrez gene summary

 The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q12

Chromosome location (bp)

 67544032 - 67730619

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169083 (version 83.38)

Entrez gene

 367

UniProt

 P10275 (UniProt - Evidence at protein level)

neXtProt

 NX_P10275

Antibodypedia

 AR antibodies

PROTEIN BROWSER
AR-001
AR-002
AR-004
AR-201
AR-202
AR-203
AR-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AR-001
ENSP00000363822
ENST00000374690
A0A0B4J1T2 [Direct mapping]
Androgen receptor
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001701 [in utero embryonic development]
GO:0003073 [regulation of systemic arterial blood pressure]
GO:0003382 [epithelial cell morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007283 [spermatogenesis]
GO:0007338 [single fertilization]
GO:0008270 [zinc ion binding]
GO:0008584 [male gonad development]
GO:0009566 [fertilization]
GO:0009987 [cellular process]
GO:0010468 [regulation of gene expression]
GO:0019102 [male somatic sex determination]
GO:0030521 [androgen receptor signaling pathway]
GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway]
GO:0033327 [Leydig cell differentiation]
GO:0035264 [multicellular organism growth]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043565 [sequence-specific DNA binding]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0048608 [reproductive structure development]
GO:0048638 [regulation of developmental growth]
GO:0048645 [organ formation]
GO:0048808 [male genitalia morphogenesis]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050790 [regulation of catalytic activity]
GO:0060520 [activation of prostate induction by androgen receptor signaling pathway]
GO:0060571 [morphogenesis of an epithelial fold]
GO:0060599 [lateral sprouting involved in mammary gland duct morphogenesis]
GO:0060685 [regulation of prostatic bud formation]
GO:0060736 [prostate gland growth]
GO:0060740 [prostate gland epithelium morphogenesis]
GO:0060742 [epithelial cell differentiation involved in prostate gland development]
GO:0060748 [tertiary branching involved in mammary gland duct morphogenesis]
GO:0060749 [mammary gland alveolus development]
GO:0061458 [reproductive system development]
GO:0070974 [POU domain binding]
GO:0072520 [seminiferous tubule development]
Show all
 920 aa
99.2 kDa 		No 0
AR-002
ENSP00000379358
ENST00000396043
P10275 [Direct mapping]
Androgen receptor
F1D8N5 [Target identity:100%; Query identity:100%]
Androgen nuclear receptor variant 2
Show all
Nuclear receptors
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005102 [receptor binding]
GO:0005497 [androgen binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006810 [transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007548 [sex differentiation]
GO:0008013 [beta-catenin binding]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0016049 [cell growth]
GO:0019899 [enzyme binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030850 [prostate gland development]
GO:0042327 [positive regulation of phosphorylation]
GO:0043234 [protein complex]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045597 [positive regulation of cell differentiation]
GO:0045720 [negative regulation of integrin biosynthetic process]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045945 [positive regulation of transcription from RNA polymerase III promoter]
GO:0046983 [protein dimerization activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051117 [ATPase binding]
GO:0051259 [protein oligomerization]
GO:0090003 [regulation of establishment of protein localization to plasma membrane]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
 388 aa
44.6 kDa 		No 0
AR-004
ENSP00000421155
ENST00000504326
E7EVX6 [Direct mapping]
Androgen receptor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 644 aa
67.4 kDa 		No 0
AR-201
ENSP00000379359
ENST00000396044
F5GZG9 [Direct mapping]
Androgen receptor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 734 aa
77 kDa 		No 0
AR-202
ENSP00000482407
ENST00000612010
A0A087WZ66 [Direct mapping]
Androgen receptor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 642 aa
67.1 kDa 		No 0
AR-203
ENSP00000484033
ENST00000612452
A0A087X1B6 [Direct mapping]
Androgen receptor
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0030521 [androgen receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 737 aa
79.4 kDa 		No 0
AR-204
ENSP00000479013
ENST00000613054
A0A087WUX9 [Direct mapping]
Androgen receptor
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004882 [androgen receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030521 [androgen receptor signaling pathway]
Show all
 572 aa
59.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.