Tissue expression of CPT1C - Summary - The Human Protein Atlas

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CPT1C

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CPT1C
Gene description	Carnitine palmitoyltransferase 1C
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (cerebellum, caudate)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA014529
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

N/A

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, caudate)

GENE INFORMATION
Gene name	CPT1C (HGNC Symbol)
Synonyms	CPT1P, CPTIC, FLJ23809
Description	Carnitine palmitoyltransferase 1C (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49690898 - 49713731
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169169 (version 83.38)
Entrez gene	126129
UniProt	Q8TCG5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCG5
Antibodypedia	CPT1C antibodies

PROTEIN BROWSER

CPT1C-001	CPT1C-005	CPT1C-006	CPT1C-008	CPT1C-009	CPT1C-016	CPT1C-017	CPT1C-018	CPT1C-019	CPT1C-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPT1C-001 ENSP00000319343 ENST00000323446	Q8TCG5 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform A0A024QZE3 [Target identity:100%; Query identity:100%] Carnitine palmitoyltransferase 1C, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0006635 [fatty acid beta-oxidation] GO:0016746 [transferase activity, transferring acyl groups] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0045202 [synapse] Show all	803 aa 91 kDa	No	2
CPT1C-005 ENSP00000472579 ENST00000595031	M0R2H6 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	336 aa 37.2 kDa	No	0
CPT1C-006 ENSP00000384465 ENST00000405931	Q8TCG5 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform A0A024QZI3 [Target identity:100%; Query identity:100%] Carnitine palmitoyltransferase 1C, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0006635 [fatty acid beta-oxidation] GO:0016746 [transferase activity, transferring acyl groups] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0045202 [synapse] Show all	792 aa 89.7 kDa	No	2
CPT1C-008 ENSP00000376303 ENST00000392518	Q8TCG5 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform A0A024QZE3 [Target identity:100%; Query identity:100%] Carnitine palmitoyltransferase 1C, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006635 [fatty acid beta-oxidation] GO:0009437 [carnitine metabolic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032281 [AMPA glutamate receptor complex] GO:0045202 [synapse] Show all	803 aa 91 kDa	No	2
CPT1C-009 ENSP00000473028 ENST00000598293	Q8TCG5 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform A0A024QZE3 [Target identity:100%; Query identity:100%] Carnitine palmitoyltransferase 1C, isoform CRA_b Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004095 [carnitine O-palmitoyltransferase activity] GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0006635 [fatty acid beta-oxidation] GO:0016746 [transferase activity, transferring acyl groups] GO:0030054 [cell junction] GO:0030424 [axon] GO:0030425 [dendrite] GO:0045202 [synapse] Show all	803 aa 91 kDa	No	2
CPT1C-016 ENSP00000472453 ENST00000595969	M0R2B9 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.4 kDa	No	1
CPT1C-017 ENSP00000470221 ENST00000598396	M0QZ13 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] Show all	257 aa 29.7 kDa	No	2
CPT1C-018 ENSP00000471579 ENST00000594587	M0R115 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] Show all	178 aa 20 kDa	No	2
CPT1C-019 ENSP00000472828 ENST00000602019	M0R2V3 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	96 aa 10.8 kDa	No	1
CPT1C-020 ENSP00000471841 ENST00000597099	M0R1F9 [Direct mapping] Carnitine O-palmitoyltransferase 1, brain isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	81 aa 9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.