Expression of CA5B in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Carbonic anhydrase VB, mitochondrial

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Melanoma

STAINING SUMMARY

HPA012618

GENE INFORMATION
Gene name	CA5B
Synonyms
Description	Carbonic anhydrase VB, mitochondrial (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	15688830 - 15788409
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169239 (version 83.38)
Entrez gene	11238
UniProt	Q9Y2D0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2D0
Antibodypedia	CA5B antibodies

PROTEIN BROWSER

CA5B-005	CA5B-007	CA5B-009	CA5B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA5B-005 ENSP00000314099 ENST00000318636	Q9Y2D0 [Direct mapping] Carbonic anhydrase 5B, mitochondrial A0A024RBW9 [Target identity:100%; Query identity:100%] Carbonic anhydrase VB, mitochondrial, isoform CRA_c Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0044281 [small molecule metabolic process] Show all	317 aa 36.4 kDa	No	0
CA5B-007 ENSP00000417553 ENST00000479740	C9JA11 [Direct mapping] Carbonic anhydrase 5B, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] Show all	136 aa 15.8 kDa	No	0
CA5B-009 ENSP00000418622 ENST00000498004	C9IZP3 [Direct mapping] Carbonic anhydrase 5B, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] Show all	76 aa 8.9 kDa	No	0
CA5B-201 ENSP00000417021 ENST00000454127	Q9Y2D0 [Direct mapping] Carbonic anhydrase 5B, mitochondrial A0A024RBW9 [Target identity:100%; Query identity:100%] Carbonic anhydrase VB, mitochondrial, isoform CRA_c Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0044281 [small molecule metabolic process] Show all	317 aa 36.4 kDa	No	0