Tissue expression of CA5B - Summary - The Human Protein Atlas

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CA5B

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CA5B
Gene description	Carbonic anhydrase VB, mitochondrial
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA012618
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CA5B
Synonyms
Description	Carbonic anhydrase VB, mitochondrial (HGNC Symbol)
Entrez gene summary	Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	15688830 - 15788409
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169239 (version 83.38)
Entrez gene	11238
UniProt	Q9Y2D0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2D0
Antibodypedia	CA5B antibodies

PROTEIN BROWSER

CA5B-005	CA5B-007	CA5B-009	CA5B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CA5B-005 ENSP00000314099 ENST00000318636	Q9Y2D0 [Direct mapping] Carbonic anhydrase 5B, mitochondrial A0A024RBW9 [Target identity:100%; Query identity:100%] Carbonic anhydrase VB, mitochondrial, isoform CRA_c Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0044281 [small molecule metabolic process] Show all	317 aa 36.4 kDa	No	0
CA5B-007 ENSP00000417553 ENST00000479740	C9JA11 [Direct mapping] Carbonic anhydrase 5B, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] Show all	136 aa 15.8 kDa	No	0
CA5B-009 ENSP00000418622 ENST00000498004	C9IZP3 [Direct mapping] Carbonic anhydrase 5B, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0008270 [zinc ion binding] Show all	76 aa 8.9 kDa	No	0
CA5B-201 ENSP00000417021 ENST00000454127	Q9Y2D0 [Direct mapping] Carbonic anhydrase 5B, mitochondrial A0A024RBW9 [Target identity:100%; Query identity:100%] Carbonic anhydrase VB, mitochondrial, isoform CRA_c Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004089 [carbonate dehydratase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006730 [one-carbon metabolic process] GO:0008270 [zinc ion binding] GO:0015701 [bicarbonate transport] GO:0044281 [small molecule metabolic process] Show all	317 aa 36.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.