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Cancer tissues were generally negative. Cases of prostate cancers showed moderate positivity. One case of pancreatic carcinoma showed distinct nuclear immunoreactivity.
GENE INFORMATION
Gene name
ADRB2 (HGNC Symbol)
Synonyms
ADRB2R, ADRBR, B2AR, BAR
Description
Adrenoceptor beta 2, surface (HGNC Symbol)
Entrez gene summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]