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ADRB2

GENERAL INFORMATION

Gene name

 ADRB2

Gene description

 Adrenoceptor beta 2, surface

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA003431
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Cervix, uterine

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)

GENE INFORMATION

Gene name

 ADRB2 (HGNC Symbol)

Synonyms

 ADRB2R, ADRBR, B2AR, BAR

Description

 Adrenoceptor beta 2, surface (HGNC Symbol)

Entrez gene summary

 This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q32

Chromosome location (bp)

 148825245 - 148828687

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169252 (version 83.38)

Entrez gene

 154

UniProt

 P07550 (UniProt - Evidence at protein level)

neXtProt

 NX_P07550

Antibodypedia

 ADRB2 antibodies

PROTEIN BROWSER
ADRB2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADRB2-001
ENSP00000305372
ENST00000305988
P07550 [Direct mapping]
Beta-2 adrenergic receptor
X5DQM5 [Target identity:100%; Query identity:100%]
Adrenoceptor beta 2 surface isoform A
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0001889 [liver development]
GO:0001965 [G-protein alpha-subunit binding]
GO:0001993 [regulation of systemic arterial blood pressure by norepinephrine-epinephrine]
GO:0002024 [diet induced thermogenesis]
GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure]
GO:0002028 [regulation of sodium ion transport]
GO:0002032 [desensitization of G-protein coupled receptor protein signaling pathway by arrestin]
GO:0002086 [diaphragm contraction]
GO:0003059 [positive regulation of the force of heart contraction by epinephrine]
GO:0004930 [G-protein coupled receptor activity]
GO:0004941 [beta2-adrenergic receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0008144 [drug binding]
GO:0008179 [adenylate cyclase binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0008333 [endosome to lysosome transport]
GO:0009409 [response to cold]
GO:0010765 [positive regulation of sodium ion transport]
GO:0015459 [potassium channel regulator activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0019899 [enzyme binding]
GO:0030279 [negative regulation of ossification]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030501 [positive regulation of bone mineralization]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031649 [heat generation]
GO:0031713 [B2 bradykinin receptor binding]
GO:0032403 [protein complex binding]
GO:0032570 [response to progesterone]
GO:0032781 [positive regulation of ATPase activity]
GO:0032809 [neuronal cell body membrane]
GO:0033574 [response to testosterone]
GO:0035240 [dopamine binding]
GO:0035249 [synaptic transmission, glutamatergic]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035811 [negative regulation of urine volume]
GO:0040015 [negative regulation of multicellular organism growth]
GO:0042060 [wound healing]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0043268 [positive regulation of potassium ion transport]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044849 [estrous cycle]
GO:0045453 [bone resorption]
GO:0045823 [positive regulation of heart contraction]
GO:0045909 [positive regulation of vasodilation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045986 [negative regulation of smooth muscle contraction]
GO:0048633 [positive regulation of skeletal muscle tissue growth]
GO:0050728 [negative regulation of inflammatory response]
GO:0050873 [brown fat cell differentiation]
GO:0051379 [epinephrine binding]
GO:0051380 [norepinephrine binding]
GO:0051924 [regulation of calcium ion transport]
GO:0051930 [regulation of sensory perception of pain]
GO:0060079 [excitatory postsynaptic potential]
GO:0071456 [cellular response to hypoxia]
GO:0071548 [response to dexamethasone]
GO:0071867 [response to monoamine]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0090331 [negative regulation of platelet aggregation]
GO:0097421 [liver regeneration]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901098 [positive regulation of autophagosome maturation]
GO:1904504 [positive regulation of lipophagy]
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 413 aa
46.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.