Expression of GP2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glycoprotein 2 (zymogen granule membrane)

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015739	HPA016668

GENE INFORMATION
Gene name	GP2
Synonyms
Description	Glycoprotein 2 (zymogen granule membrane) (HGNC Symbol)
Entrez gene summary	This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	20309572 - 20327808
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169347 (version 83.38)
Entrez gene	2813
UniProt	P55259 (UniProt - Evidence at transcript level)
neXtProt	NX_P55259
Antibodypedia	GP2 antibodies

PROTEIN BROWSER

GP2-001	GP2-002	GP2-003	GP2-004	GP2-006	GP2-007	GP2-008	GP2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GP2-001 ENSP00000304044 ENST00000302555	P55259 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	534 aa 59.1 kDa	Yes	1
GP2-002 ENSP00000343861 ENST00000341642	P55259 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	387 aa 43 kDa	Yes	1
GP2-003 ENSP00000370765 ENST00000381360	P55259 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	390 aa 43.4 kDa	Yes	1
GP2-004 ENSP00000370767 ENST00000381362	P55259 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0031225 [anchored component of membrane] GO:0070062 [extracellular exosome] Show all	537 aa 59.5 kDa	Yes	1
GP2-006 ENSP00000461061 ENST00000572478	I3L486 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		163 aa 18 kDa	Yes	0
GP2-007 ENSP00000461632 ENST00000572347	I3L4Y3 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 15.8 kDa	No	0
GP2-008 ENSP00000460466 ENST00000575582	I3L3I2 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 16 kDa	Yes	0
GP2-009 ENSP00000460059 ENST00000575449	I3L2Z7 [Direct mapping] Pancreatic secretory granule membrane major glycoprotein GP2 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13.9 kDa	Yes	0