Expression of RNASE2 in cancer - Summary

CANCER ATLAS

Gene description

Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

Protein class

Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA044983

GENE INFORMATION
Gene name	RNASE2 (HGNC Symbol)
Synonyms	EDN, RAF3, RNS2
Description	Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20955452 - 20956436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169385 (version 83.38)
Entrez gene	6036
UniProt	P10153 (UniProt - Evidence at protein level)
neXtProt	NX_P10153
Antibodypedia	RNASE2 antibodies

PROTEIN BROWSER

RNASE2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASE2-001 ENSP00000303276 ENST00000304625	P10153 [Direct mapping] Non-secretory ribonuclease W0UV60 [Target identity:100%; Query identity:100%] Ribonuclease A F3; Ribonuclease, RNase A family, 2 (Liver, eosinophil-derived neurotoxin) Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004519 [endonuclease activity] GO:0004522 [ribonuclease A activity] GO:0004540 [ribonuclease activity] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0006401 [RNA catabolic process] GO:0006935 [chemotaxis] GO:0070062 [extracellular exosome] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] GO:0090501 [RNA phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	161 aa 18.4 kDa	Yes	0