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RNASE2

GENERAL INFORMATION

Gene name

 RNASE2

Gene description

 Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (bone marrow)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (spleen, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in bone marrow, spleen and in a subset of inflammatory cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA044983
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, lymph node)

GENE INFORMATION

Gene name

 RNASE2 (HGNC Symbol)

Synonyms

 EDN, RAF3, RNS2

Description

 Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 20955452 - 20956436

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169385 (version 83.38)

Entrez gene

 6036

UniProt

 P10153 (UniProt - Evidence at protein level)

neXtProt

 NX_P10153

Antibodypedia

 RNASE2 antibodies

PROTEIN BROWSER
RNASE2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNASE2-001
ENSP00000303276
ENST00000304625
P10153 [Direct mapping]
Non-secretory ribonuclease
W0UV60 [Target identity:100%; Query identity:100%]
Ribonuclease A F3; Ribonuclease, RNase A family, 2 (Liver, eosinophil-derived neurotoxin)
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0004519 [endonuclease activity]
GO:0004522 [ribonuclease A activity]
GO:0004540 [ribonuclease activity]
GO:0005576 [extracellular region]
GO:0005764 [lysosome]
GO:0006401 [RNA catabolic process]
GO:0006935 [chemotaxis]
GO:0070062 [extracellular exosome]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
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 161 aa
18.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.