Cell atlas - CKAP2L - The Human Protein Atlas

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CKAP2L

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitotic spindle

Human cell
	Cytosol
	Microtubules

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GENERAL INFORMATION
Gene name	CKAP2L
Gene description	Cytoskeleton associated protein 2-like
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitotic spindle. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitotic spindle (supported)
Additional location	In addition localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA070737
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitotic spindle. In addition localized to the cytosol.

Main location

Mitotic spindle (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070737	A-431	Mitotic spindle	Intensity	Intensity
	HPA070737	A-431	Cytosol
	HPA070737	BJ	No staining

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Mitotic spindle

GENE INFORMATION
Gene name	CKAP2L (HGNC Symbol)
Synonyms	FLJ40629, radmis
Description	Cytoskeleton associated protein 2-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	112736607 - 112764677
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169607 (version 83.38)
Entrez gene	150468
UniProt	Q8IYA6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYA6
Antibodypedia	CKAP2L antibodies

PROTEIN BROWSER

CKAP2L-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKAP2L-001 ENSP00000305204 ENST00000302450	Q8IYA6 [Direct mapping] Cytoskeleton-associated protein 2-like Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005737 [cytoplasm] GO:0005813 [centrosome] Show all	745 aa 83.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.