Cell atlas - APLF - The Human Protein Atlas

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APLF

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	APLF
Gene description	Aprataxin and PNKP like factor
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA034642
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034642	A-431	Nucleoplasm
	HPA034642	U-2 OS	Nucleoplasm
	HPA034642	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	APLF (HGNC Symbol)
Synonyms	C2orf13, MGC47799, Xip1, ZCCHH1
Description	Aprataxin and PNKP like factor (HGNC Symbol)
Entrez gene summary	C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	68467561 - 68655862
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169621 (version 83.38)
Entrez gene	200558
UniProt	Q8IW19 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IW19
Antibodypedia	APLF antibodies

PROTEIN BROWSER

APLF-001	APLF-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APLF-001 ENSP00000307004 ENST00000303795	Q8IW19 [Direct mapping] Aprataxin and PNK-like factor Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000012 [single strand break repair] GO:0000166 [nucleotide binding] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0004520 [endodeoxyribonuclease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0006302 [double-strand break repair] GO:0006974 [cellular response to DNA damage stimulus] GO:0008408 [3'-5' exonuclease activity] GO:0035861 [site of double-strand break] GO:0045191 [regulation of isotype switching] GO:0046872 [metal ion binding] GO:0051106 [positive regulation of DNA ligation] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	511 aa 57 kDa	No	0
APLF-201 ENSP00000377874 ENST00000394342		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	393 aa 44.8 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.