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UGP2

CANCER ATLAS

Gene description

 UDP-glucose pyrophosphorylase 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034696
HPA034697
HPA064836

GENE INFORMATION

Gene name

 UGP2 (HGNC Symbol)

Synonyms

 UGP1, UGPP1

Description

 UDP-glucose pyrophosphorylase 2 (HGNC Symbol)

Entrez gene summary

 The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p15

Chromosome location (bp)

 63840940 - 63891562

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169764 (version 83.38)

Entrez gene

 7360

UniProt

 Q16851 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16851

Antibodypedia

 UGP2 antibodies

PROTEIN BROWSER
«
UGP2-001
UGP2-002
UGP2-004
UGP2-005
UGP2-009
UGP2-011
UGP2-012
UGP2-021
UGP2-023
UGP2-025
UGP2-029
UGP2-030
UGP2-201
UGP2-202
UGP2-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UGP2-001
ENSP00000338703
ENST00000337130
Q16851 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003983 [UTP:glucose-1-phosphate uridylyltransferase activity]
GO:0005515 [protein binding]
GO:0005536 [glucose binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006011 [UDP-glucose metabolic process]
GO:0006065 [UDP-glucuronate biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008152 [metabolic process]
GO:0019255 [glucose 1-phosphate metabolic process]
GO:0032557 [pyrimidine ribonucleotide binding]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052695 [cellular glucuronidation]
GO:0070062 [extracellular exosome]
GO:0070569 [uridylyltransferase activity]
Show all
 508 aa
56.9 kDa 		No 0
UGP2-002
ENSP00000377939
ENST00000394417
Q16851 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003983 [UTP:glucose-1-phosphate uridylyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006011 [UDP-glucose metabolic process]
GO:0006065 [UDP-glucuronate biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008152 [metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052695 [cellular glucuronidation]
GO:0070062 [extracellular exosome]
GO:0070569 [uridylyltransferase activity]
Show all
 497 aa
55.7 kDa 		No 0
UGP2-004
ENSP00000411803
ENST00000445915
E7EUC7 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003983 [UTP:glucose-1-phosphate uridylyltransferase activity]
GO:0006011 [UDP-glucose metabolic process]
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 517 aa
57.8 kDa 		No 0
UGP2-005
ENSP00000420793
ENST00000467648
Q16851 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003983 [UTP:glucose-1-phosphate uridylyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006006 [glucose metabolic process]
GO:0006011 [UDP-glucose metabolic process]
GO:0006065 [UDP-glucuronate biosynthetic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008152 [metabolic process]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0052695 [cellular glucuronidation]
GO:0070062 [extracellular exosome]
GO:0070569 [uridylyltransferase activity]
Show all
 497 aa
55.7 kDa 		No 0
UGP2-009
ENSP00000418375
ENST00000484142
C9J6Q0 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.6 kDa 		No 0
UGP2-011
ENSP00000419548
ENST00000482668
C9JTZ5 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 105 aa
12 kDa 		No 0
UGP2-012
ENSP00000417286
ENST00000480679
C9J3M0 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 38 aa
4.4 kDa 		No 0
UGP2-021
ENSP00000419442
ENST00000488245
C9JUW1 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 135 aa
15.2 kDa 		No 0
UGP2-023
ENSP00000419335
ENST00000475462
C9JVG3 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 171 aa
19.5 kDa 		No 0
UGP2-025
ENSP00000420131
ENST00000497883
C9JQU9 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 175 aa
20 kDa 		No 0
UGP2-029
ENSP00000420342
ENST00000491621
C9JNZ1 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 213 aa
24.3 kDa 		No 0
UGP2-030
ENSP00000419238
ENST00000472047
C9JWG0 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 150 aa
16.9 kDa 		No 0
UGP2-201
ENSP00000482043
ENST00000613823
A0A087WYS1 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003983 [UTP:glucose-1-phosphate uridylyltransferase activity]
GO:0006011 [UDP-glucose metabolic process]
GO:0008152 [metabolic process]
GO:0070569 [uridylyltransferase activity]
Show all
 508 aa
57 kDa 		No 0
UGP2-202
ENSP00000486332
ENST00000626380
F8WC70 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 52 aa
5.8 kDa 		No 0
UGP2-203
ENSP00000486008
ENST00000627474
F2Z3P4 [Direct mapping]
UTP--glucose-1-phosphate uridylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 48 aa
5.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.