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ONECUT1

CANCER ATLAS

Gene description

 One cut homeobox 1

Protein class

 Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003457

GENE INFORMATION

Gene name

 ONECUT1 (HGNC Symbol)

Synonyms

 HNF-6, HNF6, HNF6A

Description

 One cut homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 52756989 - 52791078

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169856 (version 83.38)

Entrez gene

 3175

UniProt

 Q9UBC0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UBC0

Antibodypedia

 ONECUT1 antibodies

PROTEIN BROWSER
ONECUT1-001
ONECUT1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ONECUT1-001
ENSP00000302630
ENST00000305901
Q9UBC0 [Direct mapping]
Hepatocyte nuclear factor 6
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001889 [liver development]
GO:0001952 [regulation of cell-matrix adhesion]
GO:0002064 [epithelial cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006006 [glucose metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007492 [endoderm development]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031016 [pancreas development]
GO:0031018 [endocrine pancreas development]
GO:0042384 [cilium assembly]
GO:0045165 [cell fate commitment]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048536 [spleen development]
Show all
 465 aa
51 kDa 		No 0
ONECUT1-003
ENSP00000453718
ENST00000560699
H0YMS2 [Direct mapping]
Hepatocyte nuclear factor 6
Show all
Predicted intracellular proteins
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 66 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.