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ONECUT1

GENERAL INFORMATION

Gene name

 ONECUT1

Gene description

 One cut homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (gallbladder, liver, pancreas, testis)
GTEx:Group enriched (pancreas, liver, testis)
FANTOM5:Group enriched (liver, pancreas, gallbladder)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in liver and gallbladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003457
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (gallbladder, liver, pancreas, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pancreas, liver, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, pancreas, gallbladder)

GENE INFORMATION

Gene name

 ONECUT1 (HGNC Symbol)

Synonyms

 HNF-6, HNF6, HNF6A

Description

 One cut homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 52756989 - 52791078

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169856 (version 83.38)

Entrez gene

 3175

UniProt

 Q9UBC0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UBC0

Antibodypedia

 ONECUT1 antibodies

PROTEIN BROWSER
ONECUT1-001
ONECUT1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ONECUT1-001
ENSP00000302630
ENST00000305901
Q9UBC0 [Direct mapping]
Hepatocyte nuclear factor 6
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001889 [liver development]
GO:0001952 [regulation of cell-matrix adhesion]
GO:0002064 [epithelial cell development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006006 [glucose metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007492 [endoderm development]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0030183 [B cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031016 [pancreas development]
GO:0031018 [endocrine pancreas development]
GO:0042384 [cilium assembly]
GO:0045165 [cell fate commitment]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048536 [spleen development]
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 465 aa
51 kDa 		No 0
ONECUT1-003
ENSP00000453718
ENST00000560699
H0YMS2 [Direct mapping]
Hepatocyte nuclear factor 6
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Predicted intracellular proteins
Show all
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 66 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.