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HOXD4

CANCER ATLAS

Gene description

 Homeobox D4

Protein class

 Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA070349

GENE INFORMATION

Gene name

 HOXD4 (HGNC Symbol)

Synonyms

 HOX4, HOX4B

Description

 Homeobox D4 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 176151222 - 176153226

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170166 (version 83.38)

Entrez gene

 3233

UniProt

 P09016 (UniProt - Evidence at transcript level)

neXtProt

 NX_P09016

Antibodypedia

 HOXD4 antibodies

PROTEIN BROWSER
HOXD4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOXD4-001
ENSP00000302548
ENST00000306324
P09016 [Direct mapping]
Homeobox protein Hox-D4
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0009952 [anterior/posterior pattern specification]
GO:0043565 [sequence-specific DNA binding]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0048863 [stem cell differentiation]
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 255 aa
27.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.