Tissue expression of MRAP - Summary - The Human Protein Atlas

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MRAP

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MRAP
Gene description	Melanocortin 2 receptor accessory protein
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (adrenal gland, adipose tissue)
GTEx:	Group enriched (adrenal gland, adipose tissue, breast)
FANTOM5:	Group enriched (breast, adipose tissue)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues at variable levels.

DATA RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA011024
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, adipose tissue)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, adipose tissue, breast)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (breast, adipose tissue)

GENE INFORMATION
Gene name	MRAP (HGNC Symbol)
Synonyms	B27, C21orf61, FALP
Description	Melanocortin 2 receptor accessory protein (HGNC Symbol)
Entrez gene summary	This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	32291813 - 32314784
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000170262 (version 83.38)
Entrez gene	56246
UniProt	Q8TCY5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCY5
Antibodypedia	MRAP antibodies

PROTEIN BROWSER

MRAP-001	MRAP-003	MRAP-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRAP-001 ENSP00000382684 ENST00000399784	Q8TCY5 [Direct mapping] Melanocortin-2 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031780 [corticotropin hormone receptor binding] GO:0031781 [type 3 melanocortin receptor binding] GO:0031782 [type 4 melanocortin receptor binding] GO:0031783 [type 5 melanocortin receptor binding] GO:0034394 [protein localization to cell surface] GO:0050873 [brown fat cell differentiation] GO:0070996 [type 1 melanocortin receptor binding] Show all	172 aa 19.1 kDa	No	1
MRAP-003 ENSP00000306697 ENST00000303645	Q8TCY5 [Direct mapping] Melanocortin-2 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031780 [corticotropin hormone receptor binding] GO:0031781 [type 3 melanocortin receptor binding] GO:0031782 [type 4 melanocortin receptor binding] GO:0031783 [type 5 melanocortin receptor binding] GO:0034394 [protein localization to cell surface] GO:0070996 [type 1 melanocortin receptor binding] Show all	172 aa 19.1 kDa	No	1
MRAP-004 ENSP00000343661 ENST00000339944	Q8TCY5 [Direct mapping] Melanocortin-2 receptor accessory protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031780 [corticotropin hormone receptor binding] GO:0031781 [type 3 melanocortin receptor binding] GO:0031782 [type 4 melanocortin receptor binding] GO:0031783 [type 5 melanocortin receptor binding] GO:0034394 [protein localization to cell surface] GO:0070996 [type 1 melanocortin receptor binding] Show all	102 aa 11.5 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.