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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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FABP4
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Fatty acid binding protein 4, adipocyte

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA002188
CAB024961

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues were negative. Moderate to strong cytoplasmic and membranous immunoreactivity was found in some squamous cell carcinomas, renal cancers and urothelial cancers.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were in general negative. Rare cases of colorectal, cervical and urothelial cancers were moderately stained in cytoplasm.

GENE INFORMATION

Gene name

FABP4 (HGNC Symbol)

Synonyms

A-FABP, aP2

Description

Fatty acid binding protein 4, adipocyte (HGNC Symbol)

Entrez gene summary

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q21.13

Chromosome location (bp)

81478419 - 81483263

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170323 (version 83.38)

Entrez gene

2167

UniProt

P15090 (UniProt - Evidence at protein level)

neXtProt

NX_P15090

Antibodypedia

FABP4 antibodies

PROTEIN BROWSER

FABP4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FABP4-001
ENSP00000256104
ENST00000256104
P15090 [Direct mapping]
Fatty acid-binding protein, adipocyte
E7DVW4 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 104; Fatty acid binding protein 4, adipocyte
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001816 [cytokine production]
GO:0005215 [transporter activity]
GO:0005504 [fatty acid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0019433 [triglyceride catabolic process]
GO:0042632 [cholesterol homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050729 [positive regulation of inflammatory response]
GO:0050872 [white fat cell differentiation]
GO:0050873 [brown fat cell differentiation]
GO:0070062 [extracellular exosome]
GO:0071285 [cellular response to lithium ion]
Show all
132 aa
14.7 kDa
No 0

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