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Liver cancers and several renal cancers showed moderate cytoplasmic positivity. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
LRRN2 (HGNC Symbol)
Synonyms
FIGLER7, GAC1, LRANK1, LRRN5
Description
Leucine rich repeat neuronal 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
