Cell atlas - LRRN2 - The Human Protein Atlas

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LRRN2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	LRRN2
Gene description	Leucine rich repeat neuronal 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Cell line enhanced (RPMI-8226, NTERA-2, T-47d, HEL)
Protein evidence	Evidence at transcript level
Main location	Localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA029124
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226, NTERA-2, T-47d, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (approved)


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Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029124	A549	Endoplasmic reticulum
	HPA029124	SiHa	Endoplasmic reticulum
	HPA029124	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	LRRN2 (HGNC Symbol)
Synonyms	FIGLER7, GAC1, LRANK1, LRRN5
Description	Leucine rich repeat neuronal 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q32.1
Chromosome location (bp)	204617170 - 204685733
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000170382 (version 83.38)
Entrez gene	10446
UniProt	O75325 (UniProt - Evidence at transcript level)
neXtProt	NX_O75325
Antibodypedia	LRRN2 antibodies

PROTEIN BROWSER

LRRN2-001	LRRN2-002	LRRN2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRN2-001 ENSP00000356144 ENST00000367176	O75325 [Direct mapping] Leucine-rich repeat neuronal protein 2 A0A024R993 [Target identity:100%; Query identity:100%] Leucine rich repeat neuronal 5, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] Show all	713 aa 78.9 kDa	Yes	1
LRRN2-002 ENSP00000356145 ENST00000367177	O75325 [Direct mapping] Leucine-rich repeat neuronal protein 2 A0A024R993 [Target identity:100%; Query identity:100%] Leucine rich repeat neuronal 5, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] Show all	713 aa 78.9 kDa	Yes	1
LRRN2-003 ENSP00000356143 ENST00000367175	O75325 [Direct mapping] Leucine-rich repeat neuronal protein 2 A0A024R993 [Target identity:100%; Query identity:100%] Leucine rich repeat neuronal 5, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] Show all	713 aa 78.9 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.