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All cancer cells were negative. Moderate cytoplasmic staining in a subset of immune cells seen in most cancer stroma.
GENE INFORMATION
Gene name
CD14
Synonyms
Description
CD14 molecule (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
P08571 [Direct mapping] Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form
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CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001530 [lipopolysaccharide binding] GO:0001847 [opsonin receptor activity] GO:0002224 [toll-like receptor signaling pathway] GO:0002237 [response to molecule of bacterial origin] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006909 [phagocytosis] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0009408 [response to heat] GO:0009617 [response to bacterium] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0012501 [programmed cell death] GO:0016019 [peptidoglycan receptor activity] GO:0031362 [anchored component of external side of plasma membrane] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032026 [response to magnesium ion] GO:0032481 [positive regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0032729 [positive regulation of interferon-gamma production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045471 [response to ethanol] GO:0045807 [positive regulation of endocytosis] GO:0046696 [lipopolysaccharide receptor complex] GO:0050715 [positive regulation of cytokine secretion] GO:0051602 [response to electrical stimulus] GO:0070062 [extracellular exosome] GO:0070891 [lipoteichoic acid binding] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
P08571 [Direct mapping] Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form
Show all
CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)